Chemical exposure and lung function in the fragrance industry: A multi-site cross-sectional study

printing supported by . Visit Chiesi at Stand B2.10 SUNDAY, SEPTEMBER 2ND 2012 Pulmonary inflammation and levels of immunoregulatory cytokines were determined in BAL. Total serum IgE was measured in blood. The analyzes were made on days 2, 4 and 7 after induction of asthma. Results: Animals sensitized to persulfate salts showed an increase in bronchial hyperresponsiveness to methacholine and in the % of neutrophils and total IgE after inhalation of persulfate salts, compared with the control group. The animals treated with mesenchymal stem cells showed a decrease of the bronchial hyperresponsiveness to methacholine and the percentage of neutrophils and total IgE compared to the control group S. There were significant differences between groups MSC and ST2 in the levels of IFN-g, IL-13 and IL-6 that were lower in the ST2 group on day 4 after induction of asthma. Conclusions: In the described model of OA mesenchymal stem cells modified to secrete sST2 have shown anti-inflammatory capacity and attenuation of bronchial hyperresponsiveness. (1) De Vooght V, et al. Thorax 2010; 65(3):252-7 Study funded by Fis PI10/00782. P1020 Serial PEF measurements detect occupational alveolitis and occupational asthma due to metal-working fluid Vicky Moore1, Arun Dev Vellore1, Alastair Robertson1, Wendy Robertson2, Sherwood Burge1. 1Occupational Lung Disease Unit, Birmingham Heartlands Hospital, Birmingham, United Kingdom; 2Warwick Medical School, University of Warwick, Coventry, United Kingdom Introduction: Serial measurements of Peak Expiratory Flow (PEF) are the most appropriate and available method for confirming occupational asthma. Changes in PEF might also occur in alveolitis. Aims: To compare work-related changes in PEF between workers with allergic alveolitis and occupational asthma with exposure to the same metal-working fluid aerosols. Methods: Symptomatic workers with restday improvement from an engineering factory were asked to measure PEF 8 times daily for 4 weeks at home and at work before remedial action in the workplace. Allergic alveolitis was diagnosed by an expert panel from combinations of systemic symptoms with breathlessness, audible crackles in the lungs, CXR or CT scan showing compatible interstitial changes and reduced DLCO. Occupational asthma was diagnosed from work-related wheeze or breathlessness and confirmed with physiological tests including serial PEF measurements. The Oasys PEF plotter was used to calculate differences between rest and workdays for mean PEF, diurnal variation and the scores used to confirm occupational asthma (Oasys, ABC and timepoint). Results: